Drug Discovery and Development
Overview
The insights provided by Next-Generation Sequencing (NGS) into the genetic variants responsible for certain diseases allow for the discovery of new drug targets and the development of targeted therapeutics. NGS technologies can be used to generate data on genomic and epigenomic modifications, and gene expression levels, each of which is crucial for the development of therapeutics targeting genetic diseases. NGS approaches can be used at multiple stages along the clinical development pipeline, from target identification to validation.
Genomics Application in Drug Discovery and Development
Genomics supports drug discovery and development by helping researchers stratify patient populations and identify biologically relevant subgroups. This improves study design and enables a more precise evaluation of therapeutic response across different genetic backgrounds.
It also helps monitor molecular changes during preclinical and clinical research. By tracking genomic patterns associated with efficacy, resistance, and safety, genomics provides valuable evidence for optimizing drug development strategies.
